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KMID : 0616120190500040272
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Korean Journal of Pharmacognosy
2019 Volume.50 No. 4 p.272 ~ p.276
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Anti-nociceptive activity of Corylopsis gotoana
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Park Zi-Won
An Soon-Young
Yoon Seon-Hwa
Shin Youn-Chel
Lee Se-Yeoun
Cha Dong-Seok
Jeon Hoon
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Abstract
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Corylopsis gotoana has been widely used as a traditional medicine for the treatment of lots of disease including cold, edema and vomiting. However pharmacological and phytochemical studies on the C. gotoana are extremely limited. Here in this study, the author investigated the anti-nociceptive effects of the methanolic extract of Corylopsis gotoana (MCG) using various pain models. In the present study, MCG exhibited strong and dose-dependent anti-nociceptive activities on various experimental pain models including thermal nociception and chemical nociception, compared to positive control such as tramadol and indomethacin. In addition, the result from combination test using naloxone, analgesic activity of MCG was slightly reduced, indicating that MCG acts as a partial opioid receptor agonist. These results demonstrated that MCG has potent analgesic potential and thus it may be possibly used as a valuable anti-nociceptive agent.
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KEYWORD
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Corylopsis gotoana, Anti-nociception, Opioid receptor agonist
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